Ramzy's Summary...!!!

Ramzy's Virology Summary

Measles

Measles...

with Tom & Jerry!

The Iron Lung

The Iron Lung

An iron lung is a machine that enables a person to breathe when normal muscle control has been lost or the work of breathing exceeds the person's ability. It is a form of medical ventilator. Properly, it is called a negative pressure ventilator.

This Machine founded in the middle of 1900s, Used in manegment of victims of poliomyelitis to help them to survive.

"Will be discussed later"

As we know "or we will know", polio virus causes damage in the AHC "Anterior Hron Cells" which are responsible about motor movements of our muscles.

If the AHC of the Respiratofy muscles affected, the patients become unable to breathe

These mesirable patients were placed in these steel chambers to survive.

The iron lung "as we see in the above photo" is a a cylindrical steel drum. A door allowing the head and neck to remain free is then closed, forming a sealed, air-tight compartment enclosing the rest of the person's body. Pumps that control airflow periodically decrease and increase the air pressure within the chamber, and particularly, on the chest.

The small windows in this chamber help in the nursing of the patient

We can see here a pediatric department managing polio cases in the mid of 1900s "polio outbraeks"

When i was preparing this topic, i found in my old files this news about the oldest patient who survived for about 60 years in this iron lung

She died in May 2008 due to Power failure ...!

Look here...

http://www.smh.com.au/news/world/power-failure-kills-iron-lung-lady/2008/05/29/1211654160059.html

To know more see this report:

Really, i have no comment to say except ...

"Alhamd Lelah"

For another story of suffering in this machine:
http://news.bbc.co.uk/2/hi/health/3182096.stm



For more readings:
http://en.wikipedia.org/wiki/Iron_lung

http://inventors.about.com/od/istartinventions/a/iron_lung.htm

http://historical.hsl.virginia.edu/ironlung/

Guess ... what is this???

Guess ... what is this???

To every body ...

Any one can guess ... What is this???

Look carefully to the photos

try to guess

and tell us what is this

waiting your openions

here & in the facebook group

Another photo to help you

HIV...The hidden danger

HIV

It is a very importent subject

You must study very well

For your Patients

For your Exams

AND

For your self

It is the hidden danger you may face in your practice every day

Please concentrate in the following

Try to understand well

And It pleased me to recive your questions

Dr.Ahmed Ramzy

Virus Strucrue

Transmision of HIV:

Viral replication cycle:

Click the following link...

http://www.sumanasinc.com/webcontent/animations/content/hiv.html

To learn ..., test your self about the virus replication cycle.

Viral replication cycle & Antiretroviral Drugs:

"Replication & Treatment"

Clinical Pictures:

1. 
   
   Acute Infection.
2. 
   
   Chronic latency
3. 
   
   AIDS

Clnical latency:

Normal person

late ... he suffers from:

 Fatigue

 Weight loss

 Fever

 

AIDS:

 

Treatment...

mentioned before,

but... "No cure"

Recommended Site for more readings:

http://www.pbs.org/wgbh/pages/frontline/aids/

Waiting your comments

Study EBV by a nice pic & song

Kissing Disease...!



Main Symptoms...

Study EBV by a nice song

 

A question regarding eradication of chicken pox

A question regarding eradication of chicken pox

Hi Dr.Ramzy, 

I heard before that, chickenpox will be eradicated within one year... is this true????

The answer:

This fact is not true at all

because of that:

The virus, after active infection, migrate through the sensory nerves to make Latency in the supplying ganglion.

The formed Abs can't affect the viruses inside the ganglion, also the antiviral drugs

So, you can't guaranty at all  of us don't have the virus in our normal healthy state.

Regarding Smallpox, the situation is different and eradication was successful due to the following factors:

 

q
Small pox virus (virola) has a single, stable serotype.

r
Human is the only host.

s
There is no carrier state or sub-clinical infection .

t
The disease is easily recognized clinically.

u
The antibody response is prompt, so exposed person can be protected.

I hope the answer is satisfactory.

Dr.Ahmed Ramzy

Shingles vaccine: 

Shingles occur when latent herpes virus particles "escape" a dorsal root ganglion and travel along sensory nerves to the skin.

استفسار بخصوص Pathogenesis of HCV

استفسار بخصوص
Pathogenesis of HCV

 The Question:

السلام عليكم يا د. رمزى
أنا كان عندى استفسار بخصوص
pathogenesis of HCV
عايزة اعرف ايه اللى بيحصل بالظبط
هو المفروض لما بيتنقل عن طريق الدم بيلف الاول فى الدم لحد مايوصل الكبد ... وخلال الفترة دى بتقدر خلايا الجهاز المناعى انها تستقبله وتهاجمه
like dendritic cells& phagocytes .... which present the antigen to the T helper cells
T helper cells are activated & activate the B cells
then when the virus enters the hepatocyts.....T helper cells activates the CTLs that cause hepatocellular damage & necrosis
ولا ايه بالظبط
يعنى انا فاهمة كدة صح؟؟
شكرا
السلام عليكم

The answer:

السلام عليكم ورحمة الله وبركاته
ازيك يا دكتورة
سؤالك جميييل جدا جدا
ولازم كلنا نكون فاهمينة كويس اوي
لان الالتهاب الكبدي مشكلة خطيرة جدا في مصر وبنقابلها كل يوم تقريبا
 

اللي انت قلتيه مظبوط
الفيروس بعد ما بيدخل الجسم ويلف في الدم
ال phagocytic cells بتحاول تسيطر
وبتعمل Ag presentation لخلايا المناعه
معني كده ان المناعه بتتنبه ضد فيروس C؟
اه طبعا
وبيتكون اجسام مضادة  Abs
وكمان CMI in the form of specific T cells
امال ايه المشكلة...؟ وليه المناعه دي مش بتقدر عليه..؟
خلاصة الامر بعيدا عن اي تفاصيل ماتهمنيش كطالب في سنه تالته
ان الفيروس لما بيدخل خلايا الكبد بكده يكون هرب من تأثير الاجسام المضادة Abs
وده منطقي لأن الفيروس خلاص بأه intracellular

طب وال CTLs ؟
درها بيجي في المرحلة دي... لأنها شغلانتها كده
CMI
يعني تضرب الخلايا اللي فيها مشكلة
وخلايا الكبد في الحالة دي مليانه مشاكل "الفيروس طبعا"
وعلشان كده تبدأ ال CTLs في الهجوم علي الخلايا المصابه وقتلها
ده بهدف انها توقف تقدم الهجوم الرهيب للفيروس
يعني عايزه تحد من انتشاره
المشكلة الخطيرة هنا ايه
ان الخايا بتاعة الكبد اللي بتموت مش بيطلع مكانها خلايا جديدة
لأ ده بيطلع مكانها الياف
fibrous tissue
وده سبب حدوث تليف الكبد
تخليلي ان القصه بتحصل كل دقيقة في حياة المريض....!
وده معناه ايه..؟
معناه ان الكبد بيتدمر خليه خلية وجزء جزء
لغاية مايبدء الثمن الاخير منه انه يتأثر
"ماهو من فضل الله الانسان منا ممكن يعيش بحاوالي تمن خلايا الكبد"
وتبدأ هنا الكارثة....
الفشل الكبدي
liver cell faliure
بكل مضاعفاته من:
ارتفاع في ضغط الوريد الكبدي البابي
portal hypertension
وما يليه من قئ دموي ونزيف من دوالي المرئ او الشرج
استسقاء بالبطن وتورم الجسم
والغيبوبة الكبدية

وبس

يارب اكون وضحت لك الاجابه
موضوع فيروس C موضوع مهم اوي
اكيد هايكون لينا لقاءات كتيرة تاني معااااه

Chicken pox & Small pox is there a difference

Chicken pox & Small pox is there a difference...?

خلينا نسأل السؤال بالعربي احسن.....

هوا ايه الفرق بين الجديري المائي والجدري؟؟؟

نشوف مع بعض:

Antiviral Adv. Funny & illustrative

Antiviral Adv.

Funny & illustrative.

Shingles...

I've Got The Chicken Pox...!

Rash of chicken pox

This is the rash of chicken pox....Don't forget
we will see a lot of rashes.....later

And Don't worry 

This baby will cure... without any permanent scars...!

Varicella Zoster Virus VZV

Varicella Zoster Virus "VZV"

Herpes Simplex Virus

Hydrophobia in Rabies 2

h

Hydrophobia in Rabies

It is not the virus replication cycle only , but how we can build a new generation

Learn also, not the virus replication cycle, but how we can build a new generation